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1.
Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship.
Biochem Biophys Res Commun
; 482(2): 310-316, 2017 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27856253
2.
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg Med Chem
; 21(18): 5725-37, 2013 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23928071
3.
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
Bioorg Med Chem
; 21(24): 7938-54, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24169315
4.
Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice.
Eur J Pharmacol
; 723: 167-74, 2014 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24333551
5.
Antitumor activity and pharmacodynamic biomarkers of a novel and orally available small-molecule antagonist of inhibitor of apoptosis proteins.
Mol Cancer Ther
; 12(2): 230-40, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23243058
6.
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
J Med Chem
; 56(3): 1228-46, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23298277
7.
Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.
J Med Chem
; 54(14): 4998-5012, 2011 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21657270
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