Detalles de la búsqueda
1.
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury.
Xenobiotica
; : 1-30, 2024 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38315106
2.
Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver.
Drug Metab Dispos
; 51(1): 67-80, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36273823
3.
Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells.
Exp Cell Res
; 419(2): 113333, 2022 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36030969
4.
PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers.
Int J Mol Sci
; 24(4)2023 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36835365
5.
Helix 12 stabilization contributes to basal transcriptional activity of PXR.
J Biol Chem
; 297(3): 100978, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34284062
6.
Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
Drug Metab Dispos
; 50(7): 1019-1026, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35184041
7.
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate.
Drug Metab Dispos
; 50(3): 235-242, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34930785
8.
Possible Involvement of the Upregulation of ΔNp63 Expression Mediated by HER2-Activated Aryl Hydrocarbon Receptor in Mammosphere Maintenance.
Int J Mol Sci
; 23(20)2022 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36292946
9.
The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells.
Biol Pharm Bull
; 44(4): 571-578, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33790107
10.
The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.
Arch Toxicol
; 95(3): 1089-1102, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33398415
11.
In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice.
Xenobiotica
; 51(9): 968-976, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34134599
12.
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase.
Xenobiotica
; 51(9): 1060-1070, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34330191
13.
Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels.
Mol Pharmacol
; 98(5): 634-647, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32892155
14.
Application of cytochrome P450 reactivity on the characterization of chemical compounds and its association with repeated-dose toxicity.
Toxicol Appl Pharmacol
; 388: 114854, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31836524
15.
Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap-Deep Learning.
Molecules
; 25(6)2020 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32183141
16.
Functional Interaction between Pregnane X Receptor and Yes-Associated Protein in Xenobiotic-Dependent Liver Hypertrophy and Drug Metabolism.
J Pharmacol Exp Ther
; 371(3): 590-601, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31533970
17.
Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis.
Biol Pharm Bull
; 42(8): 1243-1252, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31366862
18.
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
Toxicol Appl Pharmacol
; 318: 79-87, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28108177
19.
Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.
Arch Toxicol
; 91(6): 2365-2374, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-27832320
20.
PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.
Biochem J
; 473(3): 257-66, 2016 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26574435