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1.
Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.
Clin Cancer Res
; 6(11): 4409-15, 2000 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-11106261
2.
Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats.
Cancer Chemother Pharmacol
; 46(1): 51-6, 2000.
Artículo
en Inglés
| MEDLINE | ID: mdl-10912578
3.
Effects of 5-fluorouracil on the drug-metabolizing enzymes of the small intestine and the consequent drug interaction with nifedipine in rats.
J Pharmacol Exp Ther
; 297(3): 1166-75, 2001 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-11356943
4.
Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats.
Drug Metab Dispos
; 28(10): 1162-7, 2000 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-10997934
5.
Pharmacokinetics and biological fate of 3-(2,2, 2-trimethylhydrazinium)propionate dihydrate (MET-88), a novel cardioprotective agent, in rats.
Drug Metab Dispos
; 28(6): 687-94, 2000 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-10820142
6.
Purification of a phenobarbital-inducible UDP-glucuronosyltransferase isoform from dog liver which catalyzes morphine and testosterone glucuronidation.
Arch Biochem Biophys
; 325(2): 159-66, 1996 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-8561493
7.
Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation.
Mol Pharmacol
; 60(5): 1040-8, 2001 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-11641432
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