Detalles de la búsqueda
1.
Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs).
Nucleic Acids Res
; 51(12): 5901-5910, 2023 07 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37224533
2.
Safety Assessment of Formulation Vehicles Following Intravitreal Administration in Rabbits.
Pharm Res
; 35(9): 173, 2018 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29987391
3.
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
Nucleic Acids Res
; 44(5): 2093-109, 2016 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26553810
4.
Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.
Mol Ther
; 24(10): 1771-1782, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27357629
5.
Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1.
J Pharmacol Exp Ther
; 355(2): 329-40, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26330536
6.
Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.
J Pharmacol Exp Ther
; 351(3): 709-17, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25301170
7.
Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys.
Blood
; 119(10): 2401-8, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22246038
8.
Inhibition of Complement Factor 3 in Geographic Atrophy with NGM621: Phase 1 Dose-Escalation Study Results.
Am J Ophthalmol
; 235: 131-142, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34509438
9.
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells.
Nucleic Acid Ther
; 32(6): 457-472, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35976085
10.
Glucagon-receptor-antagonism-mediated ß-cell regeneration as an effective anti-diabetic therapy.
Cell Rep
; 39(9): 110872, 2022 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35649369
11.
Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.
Exp Eye Res
; 93(3): 256-64, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21376717
12.
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.
J Pharmacol Exp Ther
; 331(1): 114-21, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19638570
13.
Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.
Toxicol Appl Pharmacol
; 238(2): 150-9, 2009 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19442681
14.
L-Carnosine: multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations.
J Pharm Pharmacol
; 61(6): 733-42, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19505363
15.
Antisense inhibition of 11betahydroxysteroid dehydrogenase type 1 improves diabetes in a novel cortisone-induced diabetic KK mouse model.
Biochem Biophys Res Commun
; 365(4): 740-5, 2008 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18029262
16.
An assessment of the ocular safety of inactive excipients following sub-tenon injection in rabbits.
J Ocul Pharmacol Ther
; 24(2): 206-16, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18345993
17.
Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates.
Nucleic Acid Ther
; 27(4): 197-208, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28541820
18.
The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to Select CpG and Non-CpG Oligonucleotides.
Nucleic Acid Ther
; 27(5): 272-284, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28605247
19.
The role of hepatocellular oxidative stress in Kupffer cell activation during 1,2-dichlorobenzene-induced hepatotoxicity.
Toxicol Sci
; 76(1): 201-11, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12915711
20.
Recommendations for safety pharmacology evaluations of oligonucleotide-based therapeutics.
Nucleic Acid Ther
; 24(4): 291-301, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24946015