Detalles de la búsqueda
1.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett
; 29(12): 1522-1531, 2019 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30981576
2.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25556090
3.
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.
Chembiochem
; 15(8): 1121-30, 2014 May 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-24797455
4.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg Med Chem Lett
; 24(1): 337-43, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24279990
5.
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 24(3): 954-62, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24433859
6.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(17): 4875-85, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23899614
7.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett
; 23(12): 3531-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23668988
8.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(20): 5488-97, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24021463
9.
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
ACS Med Chem Lett
; 11(4): 541-549, 2020 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32292562
10.
Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2).
ACS Med Chem Lett
; 9(5): 417-421, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29795752
11.
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
J Med Chem
; 61(8): 3641-3659, 2018 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29590749
12.
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett
; 8(1): 84-89, 2017 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28105280
13.
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
J Med Chem
; 59(18): 8345-68, 2016 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27541271
14.
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J Med Chem
; 59(6): 2760-79, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26919761
15.
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
J Med Chem
; 58(9): 3806-16, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25844760
16.
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.
J Med Chem
; 46(5): 868-71, 2003 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-12593666
17.
Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.
J Med Chem
; 57(13): 5714-27, 2014 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24918870
18.
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
J Med Chem
; 57(3): 770-92, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405419
19.
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
J Med Chem
; 56(12): 4921-37, 2013 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23617784
20.
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J Med Chem
; 56(16): 6413-33, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23859118