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1.
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorg Med Chem Lett
; 23(1): 209-12, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200244
2.
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorg Med Chem Lett
; 23(1): 198-202, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200252
3.
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorg Med Chem Lett
; 23(1): 203-8, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200249
4.
Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.
Bioorg Med Chem Lett
; 19(17): 5140-5, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19664921
5.
Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Bioorg Med Chem Lett
; 19(16): 4857-62, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19596574
6.
Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.
Bioorg Med Chem Lett
; 19(7): 1977-81, 2009 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19251416
7.
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
J Med Chem
; 46(20): 4236-9, 2003 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-13678401
8.
Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
J Pharm Sci
; 99(4): 2135-52, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19780144
9.
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.
J Med Chem
; 52(23): 7778-87, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19769332
10.
Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.
Bioorg Med Chem Lett
; 17(17): 4784-90, 2007 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17616396
11.
Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.
Bioorg Med Chem Lett
; 17(4): 895-901, 2007 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17169560
12.
Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics.
Biopharm Drug Dispos
; 26(9): 387-402, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16142720
13.
Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection.
Antimicrob Agents Chemother
; 48(7): 2448-54, 2004 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15215093
14.
Orally active fusion inhibitor of respiratory syncytial virus.
Antimicrob Agents Chemother
; 48(2): 413-22, 2004 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-14742189
15.
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
Proc Natl Acad Sci U S A
; 100(19): 11013-8, 2003 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-12930892
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