Detalles de la búsqueda
1.
Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial.
J Allergy Clin Immunol
; 148(3): 783-789, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33744327
2.
Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.
Drug Metab Dispos
; 47(10): 1122-1135, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31266753
3.
Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma.
Bioorg Med Chem Lett
; 29(20): 126658, 2019 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31522830
4.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett
; 29(12): 1522-1531, 2019 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30981576
5.
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Nature
; 501(7466): 232-6, 2013 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23934108
6.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25556090
7.
A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery.
J Comput Aided Mol Des
; 29(4): 327-38, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25708388
8.
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
J Immunol
; 191(5): 2205-16, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23894201
9.
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.
Chembiochem
; 15(8): 1121-30, 2014 May 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-24797455
10.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg Med Chem Lett
; 24(1): 337-43, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24279990
11.
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 24(3): 954-62, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24433859
12.
Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors.
Bioorg Med Chem Lett
; 23(21): 5923-30, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24042009
13.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(17): 4875-85, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23899614
14.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett
; 23(12): 3592-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23642482
15.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett
; 23(12): 3531-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23668988
16.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(20): 5488-97, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24021463
17.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Bioorg Med Chem Lett
; 22(24): 7627-33, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23107482
18.
Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections".
ACS Cent Sci
; 8(9): 1362, 2022 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36188352
19.
Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor.
Xenobiotica
; 40(11): 751-62, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20836753
20.
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Sci Transl Med
; 10(468)2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30463918