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1.
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.
J Med Chem
; 45(10): 2016-23, 2002 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-11985469
2.
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
J Med Chem
; 45(8): 1607-23, 2002 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11931615
3.
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.
J Med Chem
; 46(21): 4572-85, 2003 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-14521419
4.
An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents.
Antiviral Res
; 61(3): 153-9, 2004 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15168795
5.
In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease.
Antimicrob Agents Chemother
; 49(6): 2267-75, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15917520
6.
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
Antimicrob Agents Chemother
; 47(12): 3907-16, 2003 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-14638501
7.
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.
Bioorg Med Chem Lett
; 12(5): 733-8, 2002 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11858991
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