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1.
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.
Hum Mol Genet
; 25(10): 1990-2004, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26936821
2.
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.
Bioorg Med Chem Lett
; 28(15): 2641-2646, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29958762
3.
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
J Neurosci
; 34(1): 79-94, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24381270
4.
Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.
Bioorg Med Chem Lett
; 21(23): 6955-9, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22030026
5.
mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.
Sci Transl Med
; 9(403)2017 08 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28814546
6.
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
ACS Chem Neurosci
; 5(12): 1221-37, 2014 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25225882
7.
Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors.
Neuropharmacology
; 66: 122-32, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22426233
8.
Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu4.
ACS Comb Sci
; 13(2): 159-65, 2011 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21338051
9.
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.
J Med Chem
; 54(4): 1106-10, 2011 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21247167
10.
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.
J Med Chem
; 54(21): 7639-47, 2011 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21966889
11.
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).
J Med Chem
; 52(14): 4115-8, 2009 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19469556
12.
3'-Untranslated region of the type 2 bradykinin receptor is a potent regulator of gene expression.
Am J Physiol Renal Physiol
; 290(2): F456-64, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16144969
13.
Síndrome diarreico agudo (SDA) en niños atendidos en un consultorio del Servicio de Salud Metropolitano Norte 1999-2000 / Acute diarrhea syndrome in children attended at an outpatient care clinic of the Metropolitan Health Service (North) 1999-2000
Rev. chil. salud pública
; 7(1): 20-24, 2003. tab
Artículo
en Español
| LILACS | ID: lil-387956
14.
Different arrangement of human papillomavirus E2 binding sites distinguishes cutaneous types from those associated with mucosal lesions
Arch. med. res
; 27(3): 389-94, 1996. ilus
Artículo
en Inglés
| LILACS | ID: lil-200340
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