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1.
SAH derived potent and selective EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(7): 1532-7, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25746813
2.
Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug.
J Med Chem
; 64(3): 1725-1732, 2021 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33529029
3.
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
J Med Chem
; 64(13): 9056-9077, 2021 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34110834
4.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33356246
5.
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Cancer Cell
; 39(10): 1404-1421.e11, 2021 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34520734
6.
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem
; 61(3): 650-665, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29211475
7.
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(18): 8306-25, 2016 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27512831
8.
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
J Med Chem
; 54(9): 3368-85, 2011 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-21438541
9.
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(24): 11196, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27936698
10.
A Concise Stereoselective Route to the Pentacyclic Frameworks of Arisugacin A and Territrem B.
Angew Chem Int Ed Engl
; 39(21): 3876-3879, 2000 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29711687
11.
Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
Bioorg Med Chem Lett
; 16(23): 6120-3, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16973358
12.
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.
Bioorg Med Chem Lett
; 15(11): 2829-33, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911263
13.
A formal [3 + 3] cycloaddition reaction. Improved reactivity using alpha,beta-unsaturated iminium salts and evidence for reversibility of 6pi-electron electrocyclic ring closure of 1-oxatrienes.
J Org Chem
; 68(5): 1729-35, 2003 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-12608785
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