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1.
Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial.
Lancet
; 387(10016): 349-356, 2016 01 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-26547100
2.
Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.
Cardiovasc Drugs Ther
; 31(4): 445-458, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28735360
3.
Interplay between PCI access site, anticoagulant agent, and bleeding: Insights from the REGULATE-PCI randomized trial.
Am Heart J
; 223: 84-86, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32199152
4.
A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial.
Eur Heart J
; 34(31): 2481-9, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22859796
5.
Femoral Vascular Closure Devices and Bleeding, Hemostasis, and Ambulation Following Percutaneous Coronary Intervention.
J Am Heart Assoc
; 12(1): e025666, 2023 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36583436
6.
Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy.
Eur Heart J
; 32(19): 2412-9, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21724623
7.
Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.
J Allergy Clin Immunol
; 137(5): 1610-1613.e7, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26688515
8.
Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer.
J Allergy Clin Immunol
; 138(6): 1712-1715, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27522158
9.
Pathogenesis of sudden unexpected death in a clinical trial of patients with myocardial infarction and left ventricular dysfunction, heart failure, or both.
Circulation
; 122(6): 597-602, 2010 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-20660803
10.
A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial.
Am Heart J
; 161(2): 261-268.e1-2, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21315207
11.
Coagulation factor IXa as a target for treatment and prophylaxis of venous thromboembolism.
Arterioscler Thromb Vasc Biol
; 30(3): 382-7, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20139356
12.
Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes.
Eur Heart J Acute Cardiovasc Care
; 8(6): 520-526, 2019 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28403626
13.
Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study.
EuroIntervention
; 10(4): 431-8, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24929350
14.
Safety of very early sheath removal in patients treated with REG1 for acute coronary syndromes: insights from the RADAR trial.
J Invasive Cardiol
; 25(11): 593-9, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24184894
15.
Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine.
J Cardiovasc Transl Res
; 3(6): 704-16, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21080135
16.
Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial
Lancet
; 387(10016): 349-356, 2016.
Artículo
en Inglés
| SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1064588
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