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1.
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35537608
2.
3D Bioprinting of Sugar Beet Pectin through Horseradish Peroxidase-Catalyzed Cross-Linking.
ACS Appl Bio Mater
; 7(5): 3506-3514, 2024 05 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38696441
3.
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.
ACS Med Chem Lett
; 13(7): 1159-1164, 2022 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35859885
4.
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem
; 64(15): 10666-10679, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34269576
5.
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
Bioorg Med Chem Lett
; 19(13): 3525-30, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19457660
6.
Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
Bioorg Med Chem Lett
; 18(1): 159-63, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18036818
7.
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
J Med Chem
; 50(4): 603-6, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17256836
8.
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16627989
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