Detalles de la búsqueda
1.
The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity.
Immunity
; 56(8): 1727-1742.e6, 2023 08 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37379835
2.
Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy.
J Hepatol
; 80(5): 792-804, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38331327
3.
Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.
J Med Virol
; 96(3): e29502, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38450817
4.
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.
Biol Chem
; 404(4): 255-265, 2023 03 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36427206
5.
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.
Int J Mol Sci
; 24(2)2023 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36674730
6.
Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Bioorg Chem
; 129: 106192, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36265355
7.
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators.
Molecules
; 27(23)2022 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36500508
8.
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.
Molecules
; 28(1)2022 Dec 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-36615354
9.
Tumor-Selective Activation of Toll-Like Receptor 7/8 Agonist Nano-Immunomodulator Generates Safe Anti-Tumor Immune Responses upon Systemic Administration.
Angew Chem Int Ed Engl
; 61(52): e202214992, 2022 12 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36331428
10.
Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
Neurobiol Dis
; 150: 105254, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33421565
11.
Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors.
Mol Pharmacol
; 2019 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31160332
12.
Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach.
Bioorg Med Chem
; 24(18): 4424-4433, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27501911
13.
Discovery of GluN2A subtype-selective N-methyl-d-aspartate (NMDA) receptor ligands.
Acta Pharm Sin B
; 14(5): 1987-2005, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38799621
14.
Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates.
J Med Chem
; 67(5): 4234-4249, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38416116
15.
Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections.
J Med Chem
; 2024 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38764175
16.
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs.
J Med Chem
; 67(8): 6570-6584, 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38613773
17.
Identification of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.
Eur J Med Chem
; 247: 115045, 2023 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36577216
18.
Identification of the Imidazo[1,2-a]pyrazine Derivative A4 as a Potential Influenza Virus Nucleoprotein Inhibitor.
ACS Pharmacol Transl Sci
; 6(12): 1841-1850, 2023 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38093833
19.
Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles.
Acta Pharm Sin B
; 13(6): 2747-2764, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37425059
20.
Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.
RSC Med Chem
; 14(7): 1272-1295, 2023 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37484571