Detalles de la búsqueda
1.
Physiologically based pharmacokinetic-pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans.
Acta Pharmacol Sin
; 41(6): 852-865, 2020 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-31969689
2.
Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters.
Drug Metab Dispos
; 47(10): 1066-1079, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31399507
3.
Impairment of Intestinal Monocarboxylate Transporter 6 Function and Expression in Diabetic Rats Induced by Combination of High-Fat Diet and Low Dose of Streptozocin: Involvement of Butyrate-Peroxisome Proliferator-Activated Receptor-γ Activation.
Drug Metab Dispos
; 47(6): 556-566, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30923035
4.
Characteristics of ß-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats.
Acta Pharmacol Sin
; 40(8): 1106-1118, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-30792487
5.
Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model.
Drug Metab Dispos
; 46(6): 897-907, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29618575
6.
Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp.
Acta Pharmacol Sin
; 38(11): 1554-1565, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28770824
7.
Acute liver failure impairs function and expression of breast cancer-resistant protein (BCRP) at rat blood-brain barrier partly via ammonia-ROS-ERK1/2 activation.
J Neurochem
; 138(2): 282-94, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27168176
8.
Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal ß-glucuronidase activity.
Acta Pharmacol Sin
; 37(7): 1002-12, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27180979
9.
Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2-Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2-Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial.
J Clin Oncol
; : JCO2302044, 2024 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38900984
10.
Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker.
Front Pharmacol
; 13: 972411, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36210839
11.
Population pharmacokinetic modeling of pyrotinib in patients with HER2-positive advanced or metastatic breast cancer.
Eur J Pharm Sci
; 159: 105729, 2021 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33484815
12.
Short-chain fatty acids oppositely altered expressions and functions of intestinal cytochrome P4503A and P-glycoprotein and affected pharmacokinetics of verapamil following oral administration to rats.
J Pharm Pharmacol
; 72(3): 448-460, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31863502
13.
Simultaneously predict pharmacokinetic interaction of rifampicin with oral versus intravenous substrates of cytochrome P450 3A/Pglycoprotein to healthy human using a semi-physiologically based pharmacokinetic model involving both enzyme and transporter turnover.
Eur J Pharm Sci
; 134: 194-204, 2019 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31047967
14.
Increase in P-glycoprotein levels in the blood-brain barrier of partial portal vein ligation /chronic hyperammonemia rats is medicated by ammonia/reactive oxygen species/ERK1/2 activation: In vitro and in vivo studies.
Eur J Pharmacol
; 846: 119-127, 2019 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30639310
15.
Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human.
Front Pharmacol
; 7: 488, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-28018224
16.
In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes.
J Pharm Biomed Anal
; 128: 98-105, 2016 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27239758
17.
Interspecies differences in metabolism of deoxypodophyllotoxin in hepatic microsomes from human, monkey, rat, mouse and dog.
Drug Metab Pharmacokinet
; 31(4): 314-22, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27329261
18.
Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes.
Biochem Pharmacol
; 100: 98-111, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26616219
19.
Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats.
Drug Metab Pharmacokinet
; 30(3): 240-6, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25890690
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