Detalles de la búsqueda
1.
Discovery of digallic acid as XOD/URAT1 dual target inhibitor for the treatment of hyperuricemia.
Bioorg Chem
; 147: 107381, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38669781
2.
Discovery and Characterization of Moracin C as an Anti-Gouty Arthritis/Hyperuricemia Candidate by Docking-Based Virtual Screening and Pharmacological Evaluation.
J Nat Prod
; 86(9): 2091-2101, 2023 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37625387
3.
Pharmacological evaluation of a novel skeleton compound isobavachin (4',7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity.
Bioorg Chem
; 133: 106405, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36753966
4.
CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia.
Acta Pharmacol Sin
; 43(1): 121-132, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-33767379
5.
Novel natural scaffold as hURAT1 inhibitor identified by 3D-shape-based, docking-based virtual screening approach and biological evaluation.
Bioorg Chem
; 117: 105444, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34775203
6.
Two- and three-dimensional QSAR studies on hURAT1 inhibitors with flexible linkers: topomer CoMFA and HQSAR.
Mol Divers
; 24(1): 141-154, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-30868332
7.
Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats.
J Appl Toxicol
; 39(8): 1233-1244, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31066085
8.
Author Correction: CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia.
Acta Pharmacol Sin
; 43(7): 1884, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35087232
9.
Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway.
J Agric Food Chem
; 72(12): 6565-6574, 2024 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38498316
10.
Virtual Screening of Potential RoxS Inhibitors and Evaluation of Their Antimicrobial Activity in Combination with Antibiotics against Clinically Resistant Bacteria.
Antibiotics (Basel)
; 12(9)2023 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37760718
11.
Mechanism of anti-hyperuricemia of isobavachin based on network pharmacology and molecular docking.
Comput Biol Med
; 155: 106637, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36791549
12.
L-carnitine attenuated hyperuricemia-associated left ventricular remodeling through ameliorating cardiomyocytic lipid deposition.
Front Pharmacol
; 14: 1016633, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36817129
13.
Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids.
Foods
; 11(21)2022 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36360095
14.
Mutation in Transmembrane Domain 8 of Human Urate Transporter 1 Disrupts Uric Acid Recognition and Transport.
ACS Omega
; 7(38): 34621-34631, 2022 Sep 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36188325
15.
Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia.
Eur J Med Chem
; 229: 114092, 2022 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34998055
16.
Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents.
Eur J Med Chem
; 242: 114682, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36001935
17.
Characterizations of the Urate Transporter, GLUT9, and Its Potent Inhibitors by Patch-Clamp Technique.
SLAS Discov
; 26(3): 450-459, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32844721
18.
Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism.
Food Funct
; 12(18): 8274-8287, 2021 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34180933
19.
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/ß-catenin pathway.
Phytomedicine
; 87: 153585, 2021 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-34044255
20.
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Phytomedicine
; 80: 153374, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-33075645