Detalles de la búsqueda
1.
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes.
Acta Pharmacol Sin
; 43(3): 747-756, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34035488
2.
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans.
Acta Pharmacol Sin
; 43(2): 494-503, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33927359
3.
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model.
Acta Pharmacol Sin
; 43(7): 1865-1874, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-34789919
4.
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats.
Xenobiotica
; 52(1): 79-90, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-35038952
5.
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers.
Invest New Drugs
; 39(4): 1011-1018, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33506323
6.
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified.
Acta Pharmacol Sin
; 42(2): 311-322, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-32860005
7.
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor.
Acta Pharmacol Sin
; 42(3): 482-490, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-32581257
8.
Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta Pharmacol Sin
; 42(9): 1535-1546, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-33244163
9.
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer.
Acta Pharmacol Sin
; 41(10): 1366-1376, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-32235864
10.
Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration.
Acta Pharmacol Sin
; 40(2): 288-296, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29773886
11.
Metabolism and disposition of pyrotinib in healthy male volunteers: covalent binding with human plasma protein.
Acta Pharmacol Sin
; 40(7): 980-988, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30382184
12.
CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats.
Acta Pharmacol Sin
; 39(8): 1386-1392, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29283173
13.
Author Correction: Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta Pharmacol Sin
; 44(12): 2549, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37532785
14.
[Research advances in non-P450-mediated drug oxidative metabolism].
Yao Xue Xue Bao
; 52(1): 8-18, 2017 Jan.
Artículo
en Zh
| MEDLINE | ID: mdl-29911369
15.
[Simultaneous determination of donafenib and its N-oxide metabolite in human plasma by liquid chromatography-tandem mass spectrometry].
Yao Xue Xue Bao
; 52(3): 443-8, 2017 Mar.
Artículo
en Zh
| MEDLINE | ID: mdl-29979858
16.
[Metabolic research of domestically developed small molecule tyrosine kinase inhibitors].
Yao Xue Xue Bao
; 51(2): 248-56, 2016 02.
Artículo
en Zh
| MEDLINE | ID: mdl-29856578
17.
[Bioanalysis in the development of antibody-drug conjugates].
Yao Xue Xue Bao
; 51(4): 517-28, 2016 04.
Artículo
en Zh
| MEDLINE | ID: mdl-29859519
18.
[A simple method for quantification of tapentadol in dog plasma by liquid chromatography-tandem mass spectrometry and evaluation of the effects of conjugated metabolites on tapentadol].
Yao Xue Xue Bao
; 51(3): 434-8, 2016 03.
Artículo
en Zh
| MEDLINE | ID: mdl-29859025
19.
[Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study].
Yao Xue Xue Bao
; 51(12): 1885-90, 2016 12.
Artículo
en Zh
| MEDLINE | ID: mdl-29908560
20.
Potential role of organic anion transporting polypeptide 1B1 (OATP1B1) in the selective hepatic uptake of hematoporphyrin monomethyl ether isomers.
Acta Pharmacol Sin
; 36(2): 268-80, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25418376