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1.
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation.
Toxicol Pathol
; 52(1): 21-34, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38379371
2.
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies.
Toxicol Pathol
; 51(5): 264-277, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37702042
3.
Neutropenia in Cynomolgus Monkeys With Anti-Drug Antibodies Associated With Administration of Afucosylated Humanized Monoclonal Antibodies.
Toxicol Pathol
; 50(8): 910-919, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36329562
4.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30966735
5.
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.
J Pharmacol Exp Ther
; 360(1): 226-238, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27821712
6.
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.
Regul Toxicol Pharmacol
; 82: 1-13, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27773754
7.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38431835
8.
An Anti-CD22-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models.
Mol Cancer Ther
; 20(2): 340-346, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33273056
9.
Calicheamicin Antibody-Drug Conjugates with Improved Properties.
Mol Cancer Ther
; 20(6): 1112-1120, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33722856
10.
A Potent Pan-TGFß Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys.
Toxicol Sci
; 175(1): 24-34, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32077954
11.
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody.
JCI Insight
; 5(7)2020 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32271166
12.
Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models.
Cancer Res
; 67(10): 4924-32, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17510422
13.
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Mol Cancer Ther
; 17(3): 638-649, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29282299
14.
Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response.
Invest Ophthalmol Vis Sci
; 58(10): 4274-4285, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28850638
15.
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
Mol Cancer Ther
; 16(5): 871-878, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28223423
16.
EphB2 is a prognostic factor in colorectal cancer.
Clin Cancer Res
; 11(14): 5181-7, 2005 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16033834
17.
Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Mol Cancer Ther
; 18(11): 2182, 2019 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-31676543
18.
Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer.
Mol Cancer Ther
; 8(8): 2110-21, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19671761
19.
The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
J Immunol
; 178(4): 2229-40, 2007 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17277128
20.
Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF).
J Pathol
; 206(4): 466-75, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15971170
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