Detalles de la búsqueda
1.
Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor.
Bioorg Med Chem Lett
; 107: 129780, 2024 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38714262
2.
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.
Acta Pharmacol Sin
; 44(4): 791-800, 2023 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-36229599
3.
Vitrification of Mammalian Oocytes: Recent Studies on Mitochondrial Dysfunction.
Biopreserv Biobank
; 2024 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38227396
4.
Comparison of Umbilical Cord Mesenchymal Stem Cells and Fibroblasts as Donor Nuclei for Handmade Cloning in Sheep Using a Single-Cell Transcriptome.
Animals (Basel)
; 14(4)2024 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38396557
5.
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D.
J Med Chem
; 67(2): 1147-1167, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38197882
6.
Leonurine improves bovine oocyte maturation and subsequent embryonic development by reducing oxidative stress and improving mitochondrial function.
Theriogenology
; 199: 11-18, 2023 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36680865
7.
Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors.
ACS Med Chem Lett
; 14(2): 183-190, 2023 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36793426
8.
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers.
J Med Chem
; 66(6): 4197-4214, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36897932
9.
Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep.
Front Cell Dev Biol
; 11: 1177774, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37601105
10.
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
J Med Chem
; 66(5): 3327-3347, 2023 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36808996
11.
[A clinical study of thunder-fire moxibustion combined with meibomian gland massage in treatment of meibomian gand dysfunction].
Zhen Ci Yan Jiu
; 47(4): 349-53, 2022 Apr 25.
Artículo
en Zh
| MEDLINE | ID: mdl-35486015
12.
Procyanidin B2 Protects Aged Oocytes Against Meiotic Defects Through Cortical Tension Modulation.
Front Vet Sci
; 9: 795050, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35464357
13.
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations.
J Med Chem
; 65(5): 3923-3942, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35230841
14.
Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer.
Acta Pharm Sin B
; 12(5): 2619-2622, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35646528
15.
[Establishment and verification of dose effect relation curves between T cell receptor gene mutation frequency and ionizing radiation dose].
Zhonghua Yu Fang Yi Xue Za Zhi
; 45(12): 1090-2, 2011 Dec.
Artículo
en Zh
| MEDLINE | ID: mdl-22336343
16.
Effects of hypoxia on DNA hydroxymethylase Tet methylcytosine dioxygenase 2 in a KG-1 human acute myeloid leukemia cell line and its mechanism.
Oncol Lett
; 22(4): 692, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34457047
17.
[Effect on the pain and tear film stability in patients after pterygium excision treated with intradermal needling].
Zhongguo Zhen Jiu
; 39(3): 267-70, 2019 Mar 12.
Artículo
en Zh
| MEDLINE | ID: mdl-30942013
18.
The reversibility of neurofilaments decline induced by 2,5-hexanedione in rat nerve tissues.
Biochem Pharmacol
; 75(3): 737-44, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18001694
19.
Time-dependent changes of lipid peroxidation and antioxidative status in nerve tissues of hens treated with tri-ortho-cresyl phosphate (TOCP).
Toxicology
; 239(1-2): 45-52, 2007 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-17662514
20.
[Alterations of microtubule and microfilament expression in spinal cord of carbon disulfide intoxicated rats].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 25(3): 148-51, 2007 Mar.
Artículo
en Zh
| MEDLINE | ID: mdl-17498345