Detalles de la búsqueda
1.
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.
Bioorg Med Chem
; 73: 117007, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36150341
2.
Silver(I)-Catalyzed Widely Applicable Aerobic 1,2-Diol Oxidative Cleavage.
Angew Chem Int Ed Engl
; 57(10): 2616-2620, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29336100
3.
Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-κB Inhibition.
J Pharmacol Exp Ther
; 362(1): 67-77, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28450469
4.
Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships.
Bioorg Med Chem
; 23(22): 7332-9, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26526739
5.
Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids.
Bioorg Med Chem
; 22(5): 1539-47, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24518295
6.
Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis.
Eur J Med Chem
; 275: 116576, 2024 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38861808
7.
Discovery of 4-Ethoxy-6-chloro-5-azaindazoles as Novel PDE4 Inhibitors for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases.
J Med Chem
; 67(1): 728-753, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38156615
8.
Synthesis and ionophoric activities of functionalized bis(choloyl) conjugates with a rigid core.
Bioorg Med Chem Lett
; 23(11): 3145-8, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23639545
9.
Synthesis and anionophoric activities of dimeric polyamine-sterol conjugates: the impact of rigid vs. flexible linkers.
Org Biomol Chem
; 11(47): 8221-7, 2013 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24162103
10.
Microwave-assisted efficient synthesis of 2-hydroxydeoxybenzoins from the alkali degradation of readily prepared 3-aryl-4-hydroxycoumarins in water.
Chem Pharm Bull (Tokyo)
; 61(11): 1166-72, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24189303
11.
An overview of phosphodiesterase 9 inhibitors: Insights from skeletal structure, pharmacophores, and therapeutic potential.
Eur J Med Chem
; 259: 115682, 2023 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37536210
12.
Advances in the development of phosphodiesterase 7 inhibitors.
Eur J Med Chem
; 250: 115194, 2023 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36796299
13.
Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease.
Eur J Med Chem
; 238: 114503, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35689855
14.
Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments.
ACS Chem Neurosci
; 13(3): 390-405, 2022 02 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35050567
15.
Synthesis, cytotoxicities and DNA-binding affinities of benzofuran-3-ols and their fused analogs.
Chem Pharm Bull (Tokyo)
; 59(8): 1057-61, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21804255
16.
Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells.
Eur J Med Chem
; 224: 113700, 2021 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34311158
17.
Synthesis, Biological Evaluation, and Molecular Docking of Arylpyridines as Antiproliferative Agent Targeting Tubulin.
ACS Med Chem Lett
; 11(8): 1611-1619, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32832031
18.
N-[2-(6-Methyl-4-oxo-4H-chromen-3-yl)-4-oxothia-zolidin-3-yl]furan-2-carbox-amide N,N-dimethyl-formamide solvate.
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 8): o2030-1, 2009 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-21583697
19.
Discovery of Dihydropyrrol-2-ones as Novel G0/G1-Phase Arresting Agents Inducing Apoptosis.
ACS Omega
; 4(17): 17556-17560, 2019 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31656929
20.
Discovery of 2-(3,4-dialkoxyphenyl)-2-(substituted pyridazin-3-yl)acetonitriles as phosphodiesterase 4 inhibitors with anti-neuroinflammation potential based on three-dimensional quantitative structure-activity relationship study.
Chem Biol Drug Des
; 93(4): 484-502, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30588755