Detalles de la búsqueda
1.
A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema.
J Pharmacokinet Pharmacodyn
; 2024 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38734778
2.
Leveraging a physiologically-based quantitative translational modeling platform for designing B cell maturation antigen-targeting bispecific T cell engagers for treatment of multiple myeloma.
PLoS Comput Biol
; 18(7): e1009715, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35839267
3.
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Xenobiotica
; 49(11): 1251-1259, 2019 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30516093
4.
Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males.
Pharmacogenet Genomics
; 25(5): 263-9, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25794161
5.
Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption.
Pharmacogenet Genomics
; 24(3): 172-6, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24448396
6.
Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.
Pharmacogenet Genomics
; 24(2): 118-28, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24305170
7.
Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes.
Drug Metab Dispos
; 42(11): 1971-7, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25187485
8.
Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Carcinogenesis
; 34(1): 93-101, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23027621
9.
Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment.
Annu Rev Pharmacol Toxicol
; 50: 39-61, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20055697
10.
Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state.
Pharmacogenet Genomics
; 23(3): 135-41, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23344581
11.
CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people.
Pharmacogenet Genomics
; 22(6): 429-40, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22569203
12.
Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking.
Addict Biol
; 17(1): 47-61, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21521420
13.
Applications of Quantitative System Pharmacology Modeling to Model-Informed Drug Development.
Methods Mol Biol
; 2486: 71-86, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35437719
14.
Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.
Clin Transl Sci
; 15(1): 204-220, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34476898
15.
Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.
Addiction
; 117(6): 1715-1724, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34791718
16.
Physiologically-Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective.
Clin Pharmacol Ther
; 110(2): 297-310, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33270249
17.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Clin Pharmacol Ther
; 109(3): 605-618, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32686076
18.
A Minimal Physiologically-Based Pharmacokinetic Model Demonstrates Role of the Neonatal Fc Receptor (FcRn) Competition in Drug-Disease Interactions With Antibody Therapy.
Clin Pharmacol Ther
; 107(2): 423-434, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31449666
19.
A Citrulline-Based Translational Population System Toxicology Model for Gastrointestinal-Related Adverse Events Associated With Anticancer Treatments.
CPT Pharmacometrics Syst Pharmacol
; 8(12): 951-961, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31671257
20.
C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration.
Brain Sci
; 9(10)2019 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31546627