Detalles de la búsqueda
1.
Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent-Exposed Ribose-33 Pocket of tRNA-Guanine Transglycosylase.
Chemistry
; 24(39): 9957-9967, 2018 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29939431
2.
Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT).
Chemistry
; 21(1): 126-35, 2015 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25483606
3.
Strain-accelerated formation of chiral, optically active buta-1,3-dienes.
Angew Chem Int Ed Engl
; 54(1): 349-54, 2015 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25425560
4.
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Bioorg Med Chem Lett
; 20(23): 6960-5, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20974532
5.
Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.
ChemMedChem
; 11(19): 2216-2239, 2016 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27629993
6.
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.
J Med Chem
; 58(22): 9041-60, 2015 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26523333
7.
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
J Med Chem
; 53(12): 4603-14, 2010 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20491477
8.
Predicting and tuning physicochemical properties in lead optimization: amine basicities.
ChemMedChem
; 2(8): 1100-15, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17530727
9.
4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters.
Bioorg Med Chem Lett
; 16(16): 4321-5, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16762550
10.
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.
Bioorg Med Chem Lett
; 16(16): 4311-5, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16757170
11.
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.
Bioorg Med Chem Lett
; 16(16): 4305-10, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16762548
12.
Aminomethylpyridines as DPP-IV inhibitors.
Bioorg Med Chem Lett
; 14(13): 3579-80, 2004 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-15177478
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