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1.
Evaluation of antisense oligonucleotide therapy targeting Hsd17b13 in a fibrosis mice model.
J Lipid Res
; 65(3): 100514, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38309418
2.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Bioorg Med Chem
; 85: 117273, 2023 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37030194
3.
Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis.
J Magn Reson Imaging
; 56(3): 712-724, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35092323
4.
Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis.
Int J Mol Sci
; 23(12)2022 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35743140
5.
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
J Pharmacol Exp Ther
; 376(1): 29-39, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33127749
6.
Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.
J Am Soc Nephrol
; 28(11): 3300-3311, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28739650
7.
Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.
Toxicol Pathol
; 43(6): 825-37, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26085543
8.
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Cell Metab
; 34(11): 1732-1748.e5, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36323235
9.
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Cell Metab
; 3(6): 403-16, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16753576
10.
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
J Med Chem
; 64(21): 15549-15581, 2021 11 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34709814
11.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
J Pharmacol Exp Ther
; 324(2): 507-16, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18025247
12.
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
J Med Chem
; 61(3): 681-694, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29316397
13.
Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.
Metabolism
; 56(3): 380-7, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17292727
14.
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.
J Med Chem
; 60(4): 1417-1431, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28112924
15.
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
J Med Chem
; 49(13): 3770-3, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789734
16.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-17064063
17.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16759095
18.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034148
19.
Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.
Metabolism
; 55(9): 1255-62, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16919547
20.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Mol Cancer Ther
; 4(6): 977-86, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15956255