Detalles de la búsqueda
1.
Conjugates of nucleobases with triazole-hydroxamic acids for the reactivation of acetylcholinesterase and treatment of delayed neurodegeneration induced by organophosphate poisoning.
Bioorg Chem
; 141: 106858, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37774432
2.
Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer's Disease Therapy.
Int J Mol Sci
; 24(13)2023 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37445673
3.
Synthesis, Properties, and Biomedical Application of Dicationic Gemini Surfactants with Dodecane Spacer and Carbamate Fragments.
Int J Mol Sci
; 24(15)2023 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37569687
4.
Can Activation of Acetylcholinesterase by ß-Amyloid Peptide Decrease the Effectiveness of Cholinesterase Inhibitors?
Int J Mol Sci
; 24(22)2023 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38003588
5.
The Formation of Morphologically Stable Lipid Nanocarriers for Glioma Therapy.
Int J Mol Sci
; 24(4)2023 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36835043
6.
Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning.
Int J Mol Sci
; 23(23)2022 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36499322
7.
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Molecules
; 27(22)2022 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36431954
8.
Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors.
Bioorg Chem
; 94: 103455, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31791680
9.
Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry.
Molecules
; 25(6)2020 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32192230
10.
Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease.
Molecules
; 25(18)2020 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32932702
11.
Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment.
Biochem J
; 473(9): 1225-36, 2016 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26929400
12.
Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.
Bioorg Med Chem Lett
; 26(16): 4092-4, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27377327
13.
Novel slow-binding reversible acetylcholinesterase inhibitors based on uracil moieties for possible treatment of myasthenia gravis and protection from organophosphate poisoning.
Eur J Med Chem
; 246: 114949, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36462442
14.
Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes.
Pharmaceutics
; 14(12)2022 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-36559339
15.
Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning.
Pharmaceutics
; 14(9)2022 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36145698
16.
Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments.
Chem Biol Interact
; 345: 109558, 2021 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34147486
17.
α-tocopherol, a slow-binding inhibitor of acetylcholinesterase.
Chem Biol Interact
; 348: 109646, 2021 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34506764
18.
1-(3-Tert-Butylphenyl)-2,2,2-Trifluoroethanone as a Potent Transition-State Analogue Slow-Binding Inhibitor of Human Acetylcholinesterase: Kinetic, MD and QM/MM Studies.
Biomolecules
; 10(12)2020 11 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33260981
19.
A new sensitive spectrofluorimetric method for measurement of activity and kinetic study of cholinesterases.
Biochim Biophys Acta Proteins Proteom
; 1868(1): 140270, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31518689
20.
Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning.
Sci Rep
; 10(1): 16611, 2020 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33024231