Detalles de la búsqueda
1.
TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.
Antimicrob Agents Chemother
; 54(2): 718-27, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19933797
2.
Compilation and prevalence of mutations associated with resistance to non-nucleoside reverse transcriptase inhibitors.
Antivir Ther
; 14(1): 103-9, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19320243
3.
Short-term randomized proof-of-principle trial of TMC278 in patients with HIV type-1 who have previously failed antiretroviral therapy.
Antivir Ther
; 14(5): 713-22, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19704175
4.
Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial.
Lancet
; 370(9581): 49-58, 2007 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-17617272
5.
Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.
PLoS Pathog
; 2(11): e119, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17096588
6.
Resistance profile of darunavir: combined 24-week results from the POWER trials.
AIDS Res Hum Retroviruses
; 24(3): 379-88, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18327986
7.
A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides.
Antiviral Res
; 74(2): 111-24, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17097156
8.
Short-term antiviral activity of TMC278--a novel NNRTI--in treatment-naive HIV-1-infected subjects.
AIDS
; 20(13): 1721-6, 2006 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-16931936
9.
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
J Med Chem
; 48(6): 1948-64, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771439
10.
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
J Med Chem
; 48(6): 1901-9, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771434
11.
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.
J Med Chem
; 48(6): 1910-8, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771435
12.
Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
J Med Chem
; 48(6): 1965-73, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771440
13.
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
J Med Chem
; 48(6): 2072-9, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771449
14.
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
J Med Chem
; 48(6): 1813-22, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771427
15.
Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation.
AIDS
; 17(11): 1597-604, 2003 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-12853741
16.
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
J Med Chem
; 47(22): 5501-14, 2004 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15481987
17.
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
J Med Chem
; 47(10): 2550-60, 2004 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15115397
18.
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.
Drugs R D
; 5(5): 245-57, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15357624
19.
Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis.
Antivir Ther
; 16(1): 99-108, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21311113
20.
Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989-2009).
Antiviral Res
; 85(1): 75-90, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19781578