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1.
Population Pharmacokinetics and Exposure-Response Relationships of Baloxavir Marboxil in Influenza Patients at High Risk of Complications.
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32312784
2.
Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kδ inhibitor leniolisib.
Blood
; 130(21): 2307-2316, 2017 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28972011
3.
CYP3A but not P-gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta-specific phosphoinositide-3 kinase inhibitor leniolisib.
Biopharm Drug Dispos
; 39(8): 394-402, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-30171694
4.
Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies.
Br J Clin Pharmacol
; 78(3): 543-55, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24617631
5.
A Pharmacokinetics-Time to Alleviation of Symptoms Model to Support Extrapolation of Baloxavir Marboxil Clinical Efficacy in Different Ethnic Groups with Influenza A or B.
Clin Pharmacol Ther
; 112(2): 372-381, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35585696
6.
Pharmacokinetics, safety, and simulated efficacy of an influenza treatment, baloxavir marboxil, in Chinese individuals.
Clin Transl Sci
; 15(5): 1196-1203, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35176206
7.
Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells.
Int J Cancer
; 127(3): 513-20, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19960439
8.
Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay.
J Comput Aided Mol Des
; 23(12): 883-95, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19890608
9.
Predicting oral clearance in humans: how close can we get with allometry?
Clin Pharmacokinet
; 47(1): 35-45, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18076217
10.
Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.
Expert Opin Drug Metab Toxicol
; 3(6): 865-78, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18028030
11.
Phase Ib study of Buparlisib plus Trastuzumab in patients with HER2-positive advanced or metastatic breast cancer that has progressed on Trastuzumab-based therapy.
Clin Cancer Res
; 20(7): 1935-45, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24470511
12.
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
J Clin Oncol
; 30(3): 282-90, 2012 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22162589
13.
Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry.
Clin Pharmacokinet
; 50(5): 307-18, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21456631
14.
Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.
Drug Metab Dispos
; 35(10): 1766-80, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17620347
15.
The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.
Drug Metab Dispos
; 35(4): 649-59, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17267621
16.
Specific antibody modulates absorptive transport and metabolic activation of benzo[a]pyrene across Caco-2 monolayers.
J Pharmacol Exp Ther
; 313(2): 640-6, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15665140
17.
Immunopropylactic approaches against chemical carcinogenesis.
Vaccine
; 23(17-18): 2403-6, 2005 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15755636
18.
Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis?
Carcinogenesis
; 26(4): 835-44, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15637092
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