Detalles de la búsqueda
1.
Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci.
PLoS Pathog
; 20(6): e1011883, 2024 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38838057
2.
(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase.
Molecules
; 24(13)2019 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31247979
3.
5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents.
Acta Trop
; 234: 106607, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35907502
4.
Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH ß-Ketoacyl-ACP Synthase Inhibitor.
mSystems
; 7(2): e0145921, 2022 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35293791
5.
A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro.
Pharmaceuticals (Basel)
; 15(8)2022 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36015168
6.
Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library.
Eur J Med Chem
; 243: 114675, 2022 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36075146
7.
Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity.
Eur J Med Chem
; 244: 114878, 2022 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36332553
8.
Small Molecule-Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase.
Pharmaceuticals (Basel)
; 14(7)2021 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34358115
9.
Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.
Bioconjug Chem
; 21(7): 1190-205, 2010 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20565071
10.
Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500).
Pharmacol Res
; 62(4): 344-51, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20594939
11.
N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction.
Eur J Med Chem
; 194: 112223, 2020 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32220685
12.
Peptides Mimicking the ß7/ß8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
ACS Med Chem Lett
; 11(5): 811-817, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32435389
13.
Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.
Nucl Med Biol
; 36(1): 3-10, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19181263
14.
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Bioorg Med Chem
; 16(12): 6319-32, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18514530
15.
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
Eur J Med Chem
; 150: 206-227, 2018 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29529501
16.
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.
Eur J Med Chem
; 149: 238-247, 2018 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29501944
17.
Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships.
Nucleosides Nucleotides Nucleic Acids
; 26(6-7): 625-8, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-18066868
18.
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity.
Eur J Med Chem
; 135: 49-59, 2017 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28431354
19.
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/ß-peptide foldamers conjugated to cell-penetrating peptides.
Eur J Med Chem
; 140: 615-623, 2017 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29017116
20.
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile.
Antiviral Res
; 71(1): 15-23, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16616962