Detalles de la búsqueda
1.
Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?
Annu Rev Pharmacol Toxicol
; 60: 529-551, 2020 01 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31506008
2.
Optogenetic Reporters Delivered as mRNA Facilitate Repeatable Action Potential and Calcium Handling Assessment in Human iPSC-Derived Cardiomyocytes.
Stem Cells
; 40(7): 655-668, 2022 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35429386
3.
A greedy classifier optimization strategy to assess ion channel blocking activity and pro-arrhythmia in hiPSC-cardiomyocytes.
PLoS Comput Biol
; 16(9): e1008203, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32976482
4.
Repolarization instability and arrhythmia by IKr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers.
Europace
; 22(9): 1431-1441, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32770183
5.
Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings.
J Mol Cell Cardiol
; 136: 102-112, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31526813
6.
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes.
Stem Cell Reports
; 2024 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38876110
7.
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment.
J Pharmacol Toxicol Methods
; 117: 107206, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35926772
8.
STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells.
Cell Rep Methods
; 2(10): 100300, 2022 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36313798
9.
Safety pharmacology during the COVID pandemic.
J Pharmacol Toxicol Methods
; 111: 107089, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34182120
10.
Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery.
J Pharmacol Toxicol Methods
; 105: 106912, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32798702
11.
Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias.
Stem Cell Reports
; 15(5): 1127-1139, 2020 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33176122
12.
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format.
Stem Cell Reports
; 15(4): 983-998, 2020 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33053362
13.
Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Toxicol Sci
; 176(1): 103-123, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32421822
14.
Methodological and technological advances in safety pharmacology - New or simply nuanced?
J Pharmacol Toxicol Methods
; 99: 106604, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31254621
15.
Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report.
J Pharmacol Toxicol Methods
; 91: 36-42, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29355722
16.
Safety pharmacology methods and models in an evolving regulatory environment.
J Pharmacol Toxicol Methods
; 87: 1-6, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28461240
17.
Safety pharmacology methods and regulatory considerations evolve together.
J Pharmacol Toxicol Methods
; 93: 1-6, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29936032
Resultados
1 -
17
de 17
1
Próxima >
>>