Detalles de la búsqueda
1.
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.
Pharm Res
; 40(11): 2555-2566, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37442882
2.
Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing?
Int J Mol Sci
; 24(5)2023 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36902391
3.
Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model.
Neurobiol Dis
; 169: 105741, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35472634
4.
The Extension of the LeiCNS-PK3.0 Model in Combination with the "Handshake" Approach to Understand Brain Tumor Pathophysiology.
Pharm Res
; 39(7): 1343-1361, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35258766
5.
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model.
Pharm Res
; 39(7): 1303-1319, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35606598
6.
Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations.
J Pharmacokinet Pharmacodyn
; 48(5): 725-741, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34142308
7.
Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.
Int J Mol Sci
; 22(4)2021 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33672696
8.
The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions.
Pharm Res
; 37(7): 137, 2020 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32648115
9.
Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.
Int J Mol Sci
; 21(9)2020 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32365768
10.
Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
Mol Pharm
; 16(7): 3261-3274, 2019 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31180686
11.
In Vivo Quantitative Understanding of PEGylated Liposome's Influence on Brain Delivery of Diphenhydramine.
Mol Pharm
; 15(12): 5493-5500, 2018 12 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30376346
12.
Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.
J Pharmacokinet Pharmacodyn
; 45(5): 763, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30171443
13.
Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.
J Pharmacokinet Pharmacodyn
; 45(4): 621-635, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29777407
14.
Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.
Drug Metab Dispos
; 45(2): 152-159, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27836941
15.
Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics.
Pharm Res
; 39(7): 1283-1289, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35773367
16.
A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations.
Pharm Res
; 34(2): 333-351, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27864744
17.
CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.
CNS Drugs
; 38(5): 349-373, 2024 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38580795
18.
Non-linear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix.
Br J Pharmacol
; 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38663441
19.
Utility of CSF in translational neuroscience.
J Pharmacokinet Pharmacodyn
; 40(3): 315-26, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23400635
20.
The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.
J Pharmacokinet Pharmacodyn
; 40(3): 327-42, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23539188