Detalles de la búsqueda
1.
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.
N Engl J Med
; 390(4): 301-313, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38084760
2.
Healthy volunteers in first-in-human oncology drug development for small molecules.
Br J Clin Pharmacol
; 88(4): 1773-1784, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34558113
3.
First-in-human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.
Br J Clin Pharmacol
; 88(1): 103-114, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34046921
4.
Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.
Oncologist
; 26(4): 290-e545, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33296125
5.
Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement.
Br J Clin Pharmacol
; 87(12): 4658-4669, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33931884
6.
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.
Br J Cancer
; 122(8): 1166-1174, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32147669
7.
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma.
Invest New Drugs
; 38(2): 457-467, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31065954
8.
BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies.
Oncologist
; 22(7): 864-872, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28576857
9.
Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges.
Oncologist
; 21(10): 1260-1268, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27440064
10.
A phase I, randomized, double-blind, placebo-controlled, single- and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX-128, a highly selective Nav 1.8 inhibitor, in healthy adults.
Clin Transl Sci
; 15(4): 981-993, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34958174
11.
Safety and pharmacokinetics of multiple dosing with inhalable apomorphine (AZ-009), and its efficacy in a randomized crossover study in Parkinson's disease patients.
Parkinsonism Relat Disord
; 97: 84-90, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35366574
12.
Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds.
Front Oncol
; 12: 954806, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36106110
13.
Touchscreen-based finger tapping: Repeatability and configuration effects on tapping performance.
PLoS One
; 16(12): e0260783, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34874977
14.
First-in-human administration of a live-attenuated RSV vaccine lacking the G-protein assessing safety, tolerability, shedding and immunogenicity: a randomized controlled trial.
Vaccine
; 38(39): 6088-6095, 2020 09 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32718816
15.
Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson's disease: a comparative study.
J Clin Mov Disord
; 7: 4, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32280482
16.
Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season.
Hum Vaccin Immunother
; 16(6): 1322-1326, 2020 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31674870
17.
Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.
Cancer Chemother Pharmacol
; 85(5): 917-930, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32274564
18.
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
J Clin Oncol
; 37(4): 318-327, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30557521
19.
Safety and Antitumor Activity of Pembrolizumab in Patients with Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer.
Clin Cancer Res
; 24(12): 2804-2811, 2018 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29559561
20.
89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding.
Oncotarget
; 9(37): 24737-24749, 2018 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29872502