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1.
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists.
Bioorg Med Chem Lett
; 20(5): 1752-7, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20137935
2.
Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern.
Bioorg Med Chem Lett
; 20(9): 2770-5, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20363132
3.
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies.
Bioorg Med Chem Lett
; 20(3): 1084-9, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20031412
4.
SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug.
Neuropsychopharmacology
; 32(1): 78-94, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16710314
5.
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
J Med Chem
; 48(6): 1823-38, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771428
6.
Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition.
J Med Chem
; 48(22): 6855-69, 2005 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-16250644
7.
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.
J Med Chem
; 47(3): 627-43, 2004 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-14736243
8.
Piperazinyl oxime ethers as NK-1 receptor antagonists.
Bioorg Med Chem Lett
; 16(4): 1045-8, 2006 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16289817
9.
SAR study of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees of (Ant)agonism. Selection of a potential atypical antipsychotic.
Chem Pharm Bull (Tokyo)
; 54(9): 1326-30, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16946546
10.
Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity.
Bioorg Med Chem Lett
; 15(21): 4794-8, 2005 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16140010
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