Detalles de la búsqueda
1.
The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.
Pharmacol Res
; 195: 106853, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37473876
2.
Application of proteomics to understand maturation of drug metabolizing enzymes and transporters for the optimization of pediatric drug therapy.
Drug Discov Today Technol
; 39: 31-48, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34906324
3.
The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip.
Int J Mol Sci
; 22(24)2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34948271
4.
Towards human ex vivo organ perfusion models to elucidate drug pharmacokinetics in health and disease.
Drug Metab Rev
; 52(3): 438-454, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551945
5.
Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells.
Drug Metab Dispos
; 45(4): 353-360, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28153842
6.
Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.
Mol Pharm
; 14(9): 3142-3151, 2017 09 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28767254
7.
Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life.
Drug Metab Dispos
; 44(7): 1005-13, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27103634
8.
Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health.
FASEB J
; 29(11): 4600-13, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26198450
9.
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.
Int J Cancer
; 136(1): 225-33, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24825069
10.
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Mol Pharmacol
; 85(3): 520-30, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24334255
11.
A host-microbial metabolite interaction gut-on-a-chip model of the adult human intestine demonstrates beneficial effects upon inulin treatment of gut microbiome.
Microbiome Res Rep
; 3(2): 18, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38841408
12.
Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure.
Mol Pharmacol
; 83(5): 919-29, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23429889
13.
Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies.
Biomimetics (Basel)
; 8(2)2023 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37366821
14.
Novel Explanted Human Liver Model to Assess Hepatic Extraction, Biliary Excretion and Transporter Function.
Clin Pharmacol Ther
; 114(1): 137-147, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37042227
15.
Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.
Mol Pharm
; 9(9): 2497-504, 2012 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-22812517
16.
Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants.
Lab Chip
; 22(2): 326-342, 2022 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34877953
17.
A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age-dependent differences in absorption.
Clin Transl Sci
; 15(10): 2392-2402, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35962572
18.
Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate.
Drug Metab Dispos
; 39(8): 1338-44, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21566011
19.
Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).
Drug Metab Dispos
; 37(2): 277-81, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19022939
20.
Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.
Drug Metab Dispos
; 37(4): 917-23, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19139163