Detalles de la búsqueda
1.
Population PKPD modeling of BACE1 inhibitor-induced reduction in Aß levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.
Pharm Res
; 31(3): 670-83, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24092053
2.
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
J Biol Chem
; 287(49): 41245-57, 2012 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-23048024
3.
Biotransformation of two ß-secretase inhibitors including ring opening and contraction of a pyrimidine ring.
Drug Metab Dispos
; 41(5): 1134-47, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23474650
4.
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J Med Chem
; 64(18): 13807-13829, 2021 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34464130
5.
A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression.
ACS Chem Biol
; 14(3): 543-553, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30807094
6.
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.
ACS Med Chem Lett
; 10(6): 972-977, 2019 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31223457
7.
Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.
J Med Chem
; 61(17): 7796-7813, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30095900
8.
Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ.
ChemMedChem
; 11(2): 207-16, 2016 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26553345
9.
Combining an amyloid-beta (Aß) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aß production.
FEBS J
; 282(1): 65-73, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25303711
10.
Discovery of novel potent and highly selective glycogen synthase kinase-3ß (GSK3ß) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J Med Chem
; 55(21): 9107-19, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22489897
11.
New aminoimidazoles as ß-secretase (BACE-1) inhibitors showing amyloid-ß (Aß) lowering in brain.
J Med Chem
; 55(21): 9297-311, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-23017051
12.
Design and synthesis of ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of ß-amyloid peptides.
J Med Chem
; 55(21): 9346-61, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22924815
Resultados
1 -
12
de 12
1
Próxima >
>>