Detalles de la búsqueda
1.
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Bioorg Med Chem
; 21(7): 1756-63, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23462713
2.
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.
J Med Chem
; 65(16): 11388-11403, 2022 08 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35972896
3.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33573376
4.
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
PLoS Negl Trop Dis
; 13(8): e0007636, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31381563
5.
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
PLoS Negl Trop Dis
; 13(2): e0007159, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30818326
6.
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Sci Transl Med
; 11(483)2019 03 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30867321
7.
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
J Med Chem
; 50(8): 1983-7, 2007 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17367123
8.
Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.
Metabolism
; 56(3): 380-7, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17292727
9.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-17064063
10.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16759095
11.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034148
12.
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
J Med Chem
; 48(16): 5295-304, 2005 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-16078847
13.
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
J Med Chem
; 47(17): 4213-30, 2004 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-15293993
14.
Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.
Future Med Chem
; 5(15): 1733-52, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24144410
15.
Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
J Med Chem
; 56(24): 10158-70, 2013 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24304150
16.
Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.
J Med Chem
; 55(9): 4189-204, 2012 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22536986
17.
Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists.
Bioorg Med Chem Lett
; 17(1): 40-4, 2007 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17070047
18.
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorg Med Chem Lett
; 17(7): 2005-12, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17276063
19.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.
Bioorg Med Chem Lett
; 16(7): 1811-5, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16442285
20.
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.
Bioorg Med Chem Lett
; 16(7): 1807-10, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16446092