Detalles de la búsqueda
1.
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection.
N Engl J Med
; 386(3): 220-229, 2022 01 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35045228
2.
Prevalence of Comorbid Factors in Patients With Recurrent Clostridioides difficile Infection in ECOSPOR III, a Randomized Trial of an Oral Microbiota-Based Therapeutic.
Clin Infect Dis
; 77(11): 1504-1510, 2023 11 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37539715
3.
Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.
Br J Clin Pharmacol
; 88(6): 2909-2925, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35014069
4.
Size matters: the importance of particle size in a newly developed injectable formulation for the treatment of schizophrenia.
CNS Spectr
; 25(3): 323-330, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31111801
5.
Pharmacokinetic Evaluation of a 1-Day Treatment Initiation Option for Starting Long-Acting Aripiprazole Lauroxil for Schizophrenia.
J Clin Psychopharmacol
; 38(5): 435-441, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-30015676
6.
Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial.
JAMA
; 328(20): 2062-2064, 2022 11 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36260754
7.
Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen.
J Cardiovasc Pharmacol
; 64(2): 164-71, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24691275
8.
Pharmacokinetics, safety and tolerability of mipomersen in healthy Japanese volunteers and comparison with Western subjects.
Int J Clin Pharmacol Ther
; 52(4): 314-20, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24548981
9.
Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial.
JAMA Netw Open
; 6(2): e2255758, 2023 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36780159
10.
SER-109: An Oral Investigational Microbiome Therapeutic for Patients with Recurrent Clostridioides difficile Infection (rCDI).
Antibiotics (Basel)
; 11(9)2022 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36140013
11.
Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination.
Clin Pharmacokinet
; 60(5): 637-647, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33313995
12.
Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 1071-1080, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34185436
13.
Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist.
J Pharmacol Exp Ther
; 332(2): 562-8, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19889796
14.
Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro.
Xenobiotica
; 40(10): 713-20, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20712450
15.
Physiologically-Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan.
CPT Pharmacometrics Syst Pharmacol
; 9(2): 106-114, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31919994
16.
Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate.
Clin Drug Investig
; 40(1): 55-64, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31584140
17.
Pharmacokinetics, Safety, and Tolerability of a 2-Month Dose Interval Regimen of the Long-Acting Injectable Antipsychotic Aripiprazole Lauroxil: Results From a 44-Week Phase I Study.
CNS Drugs
; 34(9): 961-972, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32621071
18.
Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study.
Prog Neuropsychopharmacol Biol Psychiatry
; 100: 109881, 2020 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32004636
19.
Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.
Drug Metab Dispos
; 37(1): 90-6, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18838505
20.
Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet.
Drug Des Devel Ther
; 13: 2941-2955, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31686778