Detalles de la búsqueda
1.
Lipid Architectonics for Superior Oral Bioavailability of Nelfinavir Mesylate: Comparative in vitro and in vivo Assessment.
AAPS PharmSciTech
; 19(8): 3584-3598, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30209788
2.
Novel nanoformulation to mitigate co-effects of drugs of abuse and HIV-1 infection: towards the treatment of NeuroAIDS.
J Neurovirol
; 23(4): 603-614, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28762183
3.
Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).
Haematologica
; 101(3): 346-55, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26659919
4.
Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
Biochem J
; 465(3): 479-88, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25377919
5.
Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer.
Br J Clin Pharmacol
; 80(2): 267-75, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25752914
6.
Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.
Mol Pharm
; 11(2): 436-44, 2014 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24364805
7.
Safety and pharmacokinetics of nelfinavir during the second and third trimesters of pregnancy and postpartum.
HIV Clin Trials
; 13(1): 46-59, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22306587
8.
Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir.
PLoS Comput Biol
; 7(4): e1002037, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21552547
9.
The effect of ß-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients.
Molecules
; 17(1): 688-702, 2012 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22241465
10.
Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.
Drug Metab Dispos
; 39(6): 1070-8, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21406602
11.
Effects of localized hydrophilic mannitol and hydrophobic nelfinavir administration targeted to olfactory epithelium on brain distribution.
AAPS PharmSciTech
; 12(2): 534-43, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21519984
12.
Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir.
Biochem Biophys Res Commun
; 402(1): 163-7, 2010 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-20937259
13.
Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes.
Biopharm Drug Dispos
; 31(2-3): 178-88, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20238377
14.
Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.
J Vet Pharmacol Ther
; 33(5): 453-60, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20840389
15.
As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina.
J Pharmacol Exp Ther
; 329(3): 1016-22, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19293388
16.
Zidovudine, lamivudine, and nelfinavir concentrations in amniotic fluid and maternal serum.
HIV Clin Trials
; 10(1): 41-7, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19362995
17.
Effects of standard and supratherapeutic doses of nelfinavir on cardiac repolarization: a thorough QT study.
J Clin Pharmacol
; 49(3): 291-300, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19246729
18.
Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite.
Br J Clin Pharmacol
; 68(5): 682-9, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19916992
19.
Pharmacokinetic study and comparative bioavailability of two nelfinavir tablet formulations in Iranian healthy volunteers after a low-dose administration.
Int J Clin Pharmacol Ther
; 47(7): 491-8, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19640357
20.
Effects of obesity induced by high-fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats.
Biopharm Drug Dispos
; 30(9): 532-41, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19862765