Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes

Bastos, Tanira Matutino; Soares, Milena Botelho Pereira; Franco, Caio Haddad; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; Freitas Junior, Lucio Holanda; Moraes, Carolina Borsoi; Ragno, Rino; Rotili, Dante; Schenkman, Sergio; Mai, Antonello; Moretti, Nilmar Silvio.
Artículo en Inglés | ARCA | ID: arc-43563

Documentos relacionados

  1. Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7.
  2. Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme.
  3. SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging.
  4. Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors.
  5. Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase.
  6. The Role of Sirtuins in the Pathogenesis of Psoriasis.
  7. The chemical biology of sirtuins.
  8. Current Trends in Sirtuin Activator and Inhibitor Development.
  9. New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies.
  10. Exponential averaging <i>versus</i> umbrella sampling for computing the QM/MM free energy barrier of the initial step of the desuccinylation reaction catalyzed by sirtuin 5.