An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation

Michael Schoof; Bryan Faust; Reuben A Saunders; Smriti Sangwan; Veronica V Rezelj; Nick Hoppe; Morgane Boone; Christian Billesboelle; Cristina Puchades; Caleigh M Azumaya; Huong T Kratochvil; Marcell Zimanyi; Ishan Deshpande; Jiahao Liang; Sasha Dickinson; Henry C Nguyen; Cynthia M Chio; Gregory E Merz; Michael C Thompson; Devan Diwanji; Kaitlin Schaefer; Aditya A Anand; Niv Dobzinski; Beth Shoshana Zha; Camille R. Simoneau; Kristoffer Leon; Kris M. White; Un Seng Chio; Meghna Gupta; Mingliang Jin; Fei Li; Yanxin Liu; Kaihua Zhang; David Bulkley; Ming Sun; Amber M Smith; Alexandrea N. Rizo; Frank Moss; Axel F. Brilot; Sergei Pourmal; Raphael Trenker; Thomas Pospiech; Sayan Gupta; Benjamin Barsi-Rhyne; Vladislav Belyy; Andrew W Barile-Hill; Silke Nock; Yuwei Liu; Nevan J. Krogan; Corie Y Ralston; Danielle L Swaney; Adolfo Garcia-Sastre; Melanie Ott; Marco Vignuzzi; - Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium; Peter Walter; Aashish Manglik.
Preprint en Inglés | PREPRINT-BIORXIV | ID: ppbiorxiv-238469