Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

Allison J Greaney; Tyler N Starr; Christopher O Barnes; Yiska Weisblum; Fabian Schmidt; Marina Caskey; Christian Gaebler; Marianna Agudelo; Shlomo Finkin; Zijun Wang; Daniel Poston; Frauke Muecksch; Theodora Hatziioannou; Paul D Bieniasz; Davide F Robbiani; Michel C Nussenzweig; Pamela J Bjorkman; Jesse D Bloom.
Preprint en Inglés | PREPRINT-BIORXIV | ID: ppbiorxiv-435863

Documentos relacionados

  1. Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.
  2. Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies.
  3. Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.
  4. Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection.
  5. Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants.
  6. Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
  7. Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
  8. High-resolution map of the Fc functions mediated by COVID-19-neutralizing antibodies.
  9. A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern.
  10. A panel of multivalent nanobodies broadly neutralizing Omicron subvariants and recombinant.