The quest for a cure for HIV remains a timely and key challenge for the HIVresearchcommunity. Despite significant scientific advances, current HIVtherapy regimens do not completely eliminate the negative impact of HIV on the immune system; and the economic impact of treating all people infected with HIV globally, for the duration of their lifetimes, presents significant challenges. This article discusses, from a multidisciplinary approach, critical social, behavioral, ethical, and economic issues permeating the HIV-cureresearch agenda. As part of a search for an HIVcure, both the perspective of patients/participants and clinical researchers should be taken into account. In addition, continued efforts should be made to involve and educate the broader community.