Bone and Osteoarthritis
Bronner, Felix.
London; Springer London; 2008.
Monografía
en Inglés
| Bibliografia | ID: bib-343958
Bone and Osteoarthritis places emphasis on themolecular and cellular events that lead to osteoarthritis,stressing the role of subchondral bone, which distinguishes thisfrom other books on the disease. A novel aspect is the attentiongiven to the possible epigenetic basis, together with a discussionof the genetics predisposing to osteoarthritis. Detailed analysesare given of the role of the synovium, of the molecular mechanismsthat lead to degradation of the cartilage matrix, of thehypertrophy of the cartilage cell, of the anabolic and catabolicroles of cytokines, may lead to novel approaches to clinicaltreatment, utilizing anabolic mediators or molecules that targetsteps in the disease process. Also discussed are animal models andhow mechano-responsiveness is compromised by mechanical injury.Orthopedics and rheumatology have become close conceptually, asadvances in bone and joint biology have enabled bench andtranslational scientists, as well as practitioners, to approachclinical problems comprehensively. Because bone plays a role ininitiating osteoarthritis, therapeutic approaches focusing on bonetissue are included in the discussion of novel treatments. Thegeneral topic of osteoarthritis is therefore a timely subject for aseries on bone biology. This book, intended for clinicians,researchers and students, provides information that will orient thenovice and update the specialist. No other book treats therelationship of bone to osteoarthritis in similar fashion orprovides a comparable underpinning of jointpathophysiology.
Biblioteca responsable:
MX25.1
Ubicación: MX25.1
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