Background:
The
radiation sterilization is one of the best
methods for sterilizing vulnerable degradation
drugs like
cefozopran hydrochloride.
Results:
Chemical stability of radiosterylized
cefozopran hydrochloride, was confirmed by spectrophotometric and chromatographic
methods. EPR studies showed that
radiation has created some radical defects whose concentration was no more than several dozen ppm. The antibacterial activity of
cefozopran hydrochloride irradiated with a
dose of 25 kGy was unaltered for
Gram-positive bacteria but changed for two Gram-negative
strains. The
radiation sterilized
cefozopran hydrochloride was not
in vitro cytotoxic against
human CCD39Lu normal
lung fibroblast cell line.
Conclusions:
Cefozopran hydrochloride in solid
state is not resistant to
radiation sterilization and this
method cannot be used for
sterilization of this compound.