Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Miranda, Matheus Barbosa de; Melo, Adriene Siqueira de; Almeida, Mariana Silva; Marinho, Silvia Martins; Oliveira Junior, Wilson; Gomes, Yara de Miranda.
Rev. Soc. Bras. Med. Trop
; 50(5): 689-692, Sept.-Oct. 2017. graf
Artículo
en Inglés
| LILACS | ID: biblio-1041423
Abstract
INTRODUCTION:
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.METHODS:
The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry.RESULTS:
Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease.CONCLUSIONS:
These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.
Biblioteca responsable:
BR1.1
Texto completo
Documentos relacionados