New cathepsin V inhibitor from stems of Bowdichia virgilioides
Silva, Taynara L.; Fernandes, João B.; Silva, M. Fátima das G.F. da; Consolaro, Helder N.; Sousa, Lorena R.F. de; Vieira, Paulo C..
Rev. bras. farmacogn
; 29(4): 491-494, July-Aug. 2019. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-1042278
Abstract Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds lupeol, lupenone, β-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydroxy-7-methoxyisoflavone, 7,3′-dihydroxy-4′-methoxyisoflavone, and 5,4′-dihydroxy-7′-methoxyisoflavone. Structures of compounds were stablished by 1D and 2D NMR, and MS experiments. Among the isolated compounds, trans p-coumaric acid ester derivative and 8-methoxycoumestrol showed significant inhibition on cathepsin V, which is up to now unexplored.
Biblioteca responsable:
BR1.1
Texto completo
Documentos relacionados