Toxicological properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays / Propriedades toxicológicas de um extrato aquoso de folhas de Aristolochia triangularis utilizando os bioensaios de letalidade com Artemia salina e Allium cepa
Silva, José Darlan Alves da; Nogueira, Cláudio Rodrigo; Vieira, Maria do Carmo; Heredia-Vieira, Silvia Cristina; Barufatti, Alexeia; Crispim, Bruno do Amaral; Francisco, Luiza Flávia Veiga; Viana, Lucilene Finoto; Cardoso, Claudia Andrea Lima.
Ciênc. rural (Online)
; 49(8): e20190091, 2019. tab
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| LILACS | ID: biblio-1045419
ABSTRACT The aqueous extract of Aristolochia triangularis leaves showed activity against Artemia salina larvae, with an LD50 of 370.6 µg/mL. In experiments with Allium cepa seeds, the extract caused a 51.26% reduction in the germination index, inhibited mean root growth, and was cytotoxic at concentrations of 668 and 2,000 µg/mL. Its antioxidant activity was additionally assessed in this research and the ferric reducing antioxidant power value was found to be 391.2 µM/g. Such health-beneficial property can be attributed partly to the total phenolic content, spectrophotometrically determined as 52.67 mg/g. The occurrence of cytotoxicity suggested caution when consuming teas from A. triangularis leaves for medicinal purposes, and equally reveals the need for further studies to investigate their adverse effects.
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