Gender-related differences on short- and long-term outcomes of patients undergoing transcatheter aortic valve implantation
Katz, Marcelo; Nunes Filho, Antonio Carlos Bacelar; Caixeta, Adriano; Carvalho, Luiz Antonio; Sarmento-Leite, Rogerio; Lemos Neto, Pedro Alves; Sao Thiago, Luiz Eduardo Koenig; Oliveira, Adriano Dias Dourado; Marino, Marcos Antonio; Tumelero, Rogerio Tadeu; Perin, Marco Antonio; Abizaid, Alexandre; Tarasoutchi, Flavio; Brito Junior, Fabio Sandoli.
Catheter Cardiovasc Interv
; 89(3): 429-436, 2017.
Artículo
en Inglés
| SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1061861
OBJECTIVES:
This study aimed to compare gender-related differences in outcomes of patients undergoing TAVI over a long-term follow-up period.BACKGROUND:
Transcatheter aortic valve implantation (TAVI) has been considered the standard therapy for patients with inoperable or high-risk symptomatic aortic stenosis. The influence of gender-related differences in outcomes of patients undergoing TAVI is currently on debate.METHODS:
From January 2008 to January 2015, 819 patients (49% men) underwent TAVI and were included in a multicenter Brazilian registry. Patients were followed-up and clinical outcomes were evaluated according to the updated Valve Academic Research Consortium-2 criteria.RESULTS:
Mean follow-up was 497 ± 478 days. Compared with women, men had a lower rate of major or life-threatening bleeding (12.0% vs. 20.6%; HR = 0.57 [95CI% 0.40-0.81]; P = 0.001), and major vascular complications (6% vs. 11.7%; HR = 0.50 [95CI% 0.31-0.82]; P = 0.004). At 30 days, all-cause mortality was lower in men than in women (6.5% vs. 11.5%; P = 0.013), however, cumulative all-cause mortality was similar between groups (25.9% vs. 29.7%, men and women, respectively, HR = 0.92 [95CI% 0.71-1.19]; P = 0.52) over the entire follow-up period. By adjusted Cox regression model, renal function, diabetes, peripheral artery disease, and chronic obstructive pulmonary disease (COPD) remained independently predictors of all-cause mortality...
Biblioteca responsable:
BR79.1
Ubicación: BR79.1
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