Introduction:
Quincke´s
Scholarship deals with themes related to neuroinmunology and the
complement system.
Objective:
Describe the most recent advances of the Vll Edition of Quincke´s
Scholarship.
Methods:
Publications pertaining to Quincke´s
Scholarship were selected and revised from the
work group of the Central Lab of
Cerebrospinal fluid (LABCEL).
Results:
The principal topic was the C1q
protein; initiator of the clasic
complement pathway. From the analisis of the molecular concentration of this
protein, its transference and the correlations between the concentration of C1q
protein in
cerebrospinal fluid (LCR) and the quotient of
albumin (QAlb) between LCR and
plasma it is hypothesized that an intratecal synthesis of the C1q in
patients with a disfunction of the
blood-brain barrier. The most recently discovered pathway in the activation of the
complement is the
lectin pathway. The
diffusion of the
MASP-3
protein from
blood to LCR is proof that the
MASP-3 is synthesized in the leptomeninges. The reibergram is useful to evaluate the inmune response in
patients with
neurological manifestations caused by the
dengue virus, and
patients with
multiple sclerosis.
Conclusions:
The Vll Edition of Quincke´s
Scholarship dealt with C1q
protein and recently discovered themes of the
lectin pathway and the use of the reibergram(AU)