Aims:
Influenza A virus (IAV) can cause severe acute respiratory
infection (SARI), and
disease outcome may be associated with changes in the
microbiome of the
nasopharynx. This is a
pilot study to characterize the
microbiome of the
nasopharynx in
patients hospitalized with SARI, infected and not infected by IAV.
Methods and
Results:
Using target sequencing of the
16S rRNA gene, we assessed the bacterial
community of nasopharyngeal aspirate samples and compared the
microbiome of
patients infected with IAV with the
microbiome of
patients who were negative for IAV. We observed differences in the relative abundance of
Proteobacteria and
Firmicutes between SARI
patients, with
Streptococcus being enriched and
Pseudomonas underrepresented in IAV
patients compared with
patients who were not infected with IAV.
Conclusion:
Pseudomonas taxon seems to be in high frequency on the
nasopharynx of SARI
patients with nonIAV
infection and might present a negative
association with
Streptococcus taxon. Microbial profile appears to be different between SARI
patients infected or not infected with IAV.