The present study investigated the
association of the non-steroidal anti-inflammatory
drug ibuprofen with
itraconazole,
fluconazole and
amphotericin B against
Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and
in vitro interactions were evaluated using checkerboard microdilution
method. Synergism was demonstrated between
azoles and
ibuprofen for most isolates. However, no synergistic effects were seen when
amphotericin B was combined with
ibuprofen. Therefore, our results suggest that
ibuprofen presents clinical potential when combined with
azole drugs in the
treatment of
cryptococcosis.