Influence of Polymorphism of Vitamin D Receptor (Fok I) on Hypertension
Nunes, Ivone Freires de Oliveira Costa; Pinho, Flaviane Alves de; Cruz, Maria do Socorro Pires e; Paiva, Adriana de Azevedo; Carvalho, Cecilia Maria Resende Gonçalves de.
Braz. arch. biol. technol
; 63: e20190403, 2020. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-1132232
Abstract Evidence suggests that polymorphisms in the gene encoding a vitamin D receptor might affect blood pressure. The objective of this systematic review was to investigate the association between hypertension and vitamin D receptor (Fok I) gene polymorphism. A literature search was performed according to the PRISMA guidelines using the MEDLINE®/PubMed, Scopus, Cochrane Library CENTRAL, SciELO, and LILACS databases. The quality of case-control or cohort studies and studies based on cross-sectional methodology was evaluated using the Newcastle-Ottawa Scale and the protocol of Loney and coauthors [25], respectively. In this systematic literature search, 215 publications were identified, of which 10 were analyzed, including seven case-control studies, two cross-sectional studies, and one cohort study. The association between Fok I polymorphism and hypertension was reported in 60% of the publications and the risk for hypertension was shown to be related to FF and ff genotypes. In addition, Fok I polymorphism was shown to increase plasma renin activity, which plays an important role in regulating blood pressure. However, no association was observed between Fok I polymorphism and serum vitamin D levels. In conclusion, Fok I polymorphism plays an important role in hypertension.
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