Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

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Oliveira, Saulo Gomes de; Souza, Ilana Brito Ferraz de; Constantino, Taynan da Silva; Silva, Paula Carolina Valença; Lima, Elker Lene Santos de; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho.

Rev. Soc. Bras. Med. Trop ; 54: e01452020, 2021. tab, graf

Artículo en Inglés | SES-SP, Coleciona SUS (Brasil), LILACS | ID: biblio-1143891

Abstract

INTRODUCTION:

We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.

This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.

A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.

This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Humanos Animales Esquistosomiasis/genética Lectina de Unión a Manosa/genética Polimorfismo Genético Brasil Exones/genética Estudios Retrospectivos Predisposición Genética a la Enfermedad Polimorfismo de Nucleótido Simple Genotipo Cirrosis Hepática/genética

Biblioteca responsable: BR1.1